Skip to main content

My First Blog

Hi. I guess everyone writes their first blog at some point of time. Mine is now. So here it is ... tada my first blog...

Comments

Unknown said…
Rather concise i must say :-)
April 28, 2008 at 2:02:00 AM GMT+5:30
Post a Comment

Popular posts from this blog

Butter, Oil and Zephyr

    Well, have been doing a lot of a MD simulations lately. My current favourite is implicit solvent simulations. The entire explicit solvent thing always seemed too brute force to me. Its not elegant, and nor is it computationally feasible for larger systems. Implicit solvent simulations suffer from their own problems, but I would consider their future much brighter. This is simply sue to the larger time scales that you can access using these simulations even on a normal desktop system. Larger time scales means better averages and thermodynamic properties are always averages, so better match with experiment.    Speaking of Implicit solvent simulations, Gromacs does a good job, as well as any other currently. I especially like the OBC model for calculating Born radii which I am glad to say, I copied to MUST_READ folder when it first came out. It might still be lying there, that is another thing, but at least I can appreciate when a good...
1 comment
Read more

I am a Reverend now!!!

  I have been an atheist for most of my life. I have never truly believed that God exists or such thing. More recently, I have started looking down upon people that do believe in God. Not a hatred kind of looking down upon them, but rather a pitiful look down or maybe even a cuter look down upon. Like when you see a child earnestly insisting that Santa Claus exists. You pity the child's ignorance and you find it cute, but secretly you also get a bit tense knowing that his/her ignorance cannot last very long. And, you wonder if that earnest child could really handle the news when it hits them hard.   So, in summary all I am saying is, people who believe in a God are stupid. They should grow up and really think hard about what they mean when they say they believe in God. Half of them will mutter and sputter and fail to come up with what they really believe. Most would say something asinine like "I am sure there is something out there" or "There will be chaos if n...
Post a Comment
Read more

An early essay on co-translational folding

   One of the earliest essays I wrote on the co-translational folding concept. This was for a course on protein folding that Prof Balaram takes at IISc. I am reproducing it in full, with missing punctuation marks added. At one point, I say that I have not been able to find out why it is assumed that refolding is a good substitute for in vivo protein folding. I did know even then, but I chose not to talk about it. I did so, since I cannot talk about the topic without calling everyone involved an idiot. Also, I have omitted the references as I cannot bring myself to format them properly. Rest assured that nothing I said in the essay is without literature support. Co-translational folding Introduction    Protein folding is one of the major unsolved problems of molecular biology. The problem is as follows : given that a gene encodes a unique structure (which performs a unique function), how does this information conversion take place ? it is assumed (barrin...
Post a Comment
Read more